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Oral Cephalosporin Derivatives
Cephalexin
Cefadroxil
Cefaclor
Cefixime
Type of Drug:
Semi Synthetic Cephalosporin Derivate

Therapeutic Action and Use:
Broad Spectrum Antibiotic / Antibacterial.

Preparations:
Cephradine Capsules,
Cephradine Oral Suspension
Cephradine Tablets

Product Chemistry

Common Name: Cephradine

Chemical Name:
(6R,7R)-7-[[(2R)-2-amino-2-(cyclohexa-1,4-dienyl)acetyl]amino]-3-methyl- 8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Molecular Weight: 349.41

Molecular Formula: C16H19N3O4

Chemical Serail No: (CAS No.) 38821-53-3

Packing: 25Kg in double polythene bags in corrugated container

Storage: Store at 2 - 8 �C. Protect from light and moisture.

Shelf Life: 36 months

Specifications

Appearance: A white to almost white granules/crystalline powder.

Odor: Characteristic

* Optical Rotation: +80� to +90�

Water Contents: Not more than 6.0% w/w.

pH Value: 3.5 to 6.0

Sulphated Ash: Not more than 0.2% w/w.

N,N-Dimethylaniline: Not more than 20 ppm

Related Substances:

i- Individual impurity: Not more than 0.25 %

ii- Total Impurities: Not more than 2.0 %

Contents

* Cephradine(HPLC): 96 to 102 % w/w

* Cephalexin(HPLC): Not more than 5.0% w/w

Bulk Density(tapped):

i- Compacted: Not less than 0.65g/ml

ii- Powder: Not less than 0.35g/ml

*(Based on anhydrous substances)

Pharmacopeial Quality: USP, BP, EP

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Type of Drug:
Semi Synthetic Cephalosporin Derivate

Therapeutic Action and Use:
Broad Spectrum Antibiotic / Antibacterial.

Preparations:
Cephalexin Capsules,
Cephalexin Oral Suspension,
Cephalexin Tablets

Product Chemistry

Common Name: Cephalexin

Chemical Name:
(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate

Molecular Weight: 365.4

Molecular Formula: C16H17N3O4S,H2O

Chemical Serail No: (CAS No.) 23325-78-2

Packing: 25Kg in double polythene bags in corrugated container

Storage: Store below 25�C. Protect from light and moisture.

Shelf Life: 36 months

Specifications

Appearance: A white to almost white granules/crystalline powder.

Odor: Characteristic

* Optical Rotation: +149� to +158�

Water Contents: 4.0 - 8.0 % w/w.

pH Value: 4.0 to 5.5

Clarity of Solution: (Water), Clear

Sulphated Ash: Not more than 0.2% w/w.

N,N-Dimethylaniline: Not more than 20 ppm

Related Substances:

i- 7-ADCA: Not more than 1.0%

ii- Any other impurity: Not more than 1.0%

ii- Total Impurities: Not more than 3.0%

Contents

* Cephalexin(HPLC): 95 to 102 % w/w

Bulk Density(tapped):

i- Compacted: Not less than 0.65g/ml

ii- Powder: Not less than 0.30g/ml

*(Based on anhydrous substances)

Pharmacopeial Quality: USP, BP, EP

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Type of Drug:
Semi Synthetic Cephalosporin Derivate

Therapeutic Action and Use:
Broad Spectrum Antibiotic / Antibacterial.

Preparations:
Cefadroxil Capsules,
Cefadroxil Oral Suspension

Product Chemistry

Common Name: Cefadroxil

Chemical Name:
(6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8- oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate

Molecular Weight: 381.4

Molecular Formula: C16H17N3O5S,H2O

Chemical Serail No: (CAS No.) 50370-12-2

Packing: 25Kg in double polythene bags in corrugated container

Storage: Store below 25�C. Protect from light and moisture.

Shelf Life: 36 months

Specifications

Appearance: A white to almost white crystalline powder.

Odor: Characteristic

* Optical Rotation: +165� to +178�

Water Contents: 4.0 - 6.0 % w/w.

pH Value: 4.0 to 6.0

Sulphated Ash: Not more than 0.5% w/w.

N,N-Dimethylaniline: Not more than 20 ppm

Related Substances:

i- 7-ADCA: Not more than 1.0%

ii- Any other impurity: Not more than 1.0%

ii- Total Impurities: Not more than 3.0%

Contents

* Cefadroxil(HPLC): 95 to 102 % w/w

Bulk Density(tapped):

i- Compacted: Not less than 0.65g/ml

ii- Powder: Not less than 0.35g/ml

*(Based on anhydrous substances)

Pharmacopeial Quality: USP, BP, EP

                                                                                                                     Back to Products





Type of Drug:
Semi Synthetic Cephalosporin Derivate

Therapeutic Action and Use:
Broad Spectrum Antibiotic / Antibacterial.

Preparations:
Cefaclor Capsules,
Cefaclor Oral Suspension
Cefaclor Tablets

Product Chemistry

Common Name: Cefaclor

Chemical Name:
(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate acid

Molecular Weight: 385.8

Molecular Formula: C15H14CIN3O4S,H2O

Chemical Serail No: (CAS No.): 53994-73-3

Packing: 25Kg in double polythene bags in corrugated container

Storage: Store below 25�C. Protect from light and moisture.

Shelf Life: 36 months

Specifications

Appearance: A white or slightly yellow granules/powder.

Odor: Characteristic

* Optical Rotation: +101� to +111�

Water Contents: 3.0 - 6.5 % w/w.

pH Value: 3.0 to 4.5

Related Substances:

i- Individual impurity: Not more than 0.5%

ii- Total Impurities: Not more than 2.0%

Contents

* Cefaclor(HPLC): 96 to 102 % w/w

Bulk Density(tapped):

i- Compacted: Not less than 0.65g/ml

ii- Powder: Not less than 0.35g/ml

*(Based on anhydrous substances)

Pharmacopeial Quality: USP, BP, EP

                                                                                                                     Back to Products




Type of Drug:
Semi Synthetic Cephalosporin Derivate

Therapeutic Action and Use:
Broad Spectrum Antibiotic / Antibacterial.

Preparations:
Cefixime Capsules,
Cefixime Oral Suspension

Product Chemistry

Common Name: Cefixime

Chemical Name:
(6R,7R)-7-[[(Z)-2-(2-aminothiazol-4-yl)-2-[ (carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid trihydrate

Molecular Weight: 507.5

Molecular Formula: C16H15N5O7S2,3H2O

Chemical Serail No: (CAS No.): 79350-37-1

Packing: 25Kg in double polythene bags in corrugated container

Storage: Store below 25�C. Protect from light and moisture.

Shelf Life: 36 months

Specifications

Appearance: A white or almost white granules/powder.

Odor: Characteristic

* Optical Rotation: -75� to -88�

Water Contents: 9.0 - 12.0 % w/w.

pH Value: 2.6 to 4.1

Related Substances:

i- Individual impurity: Not more than 0.5%

ii- Total Impurities: Not more than 3.0%

Contents

* Cefaclor(HPLC): 95 to 101 % w/w

Bulk Density(tapped):

i- Compacted: Not less than 0.70g/ml

ii- Powder: Not less than 0.40g/ml

*(Based on anhydrous substances)

Pharmacopeial Quality: USP, BP, EP

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